Projects

Projects are posted to help find interested individuals with appropriate expertise to implement needs

Computational Drug Discovery for Alzheimer's Disease

ABOUT THE PROJECT

Project Description

The goal of this project is to analyze publicly available, large-scale transcriptomic datasets of AD patients and age-matched controls to identify apoE genotype-specific gene expression signatures of AD and to pursue drug repositioning based on apoE genotype-specific gene expression signatures of AD. We will work with collaborators to then validate the top drug candidates in mouse models of AD. The outcomes of the proposed studies will shed light on the pathogenesis of AD and potentially identify existing drugs for treating or preventing AD.

Funding

Definitely yes

LOOKING FOR

Required Skills
  • Python
  • R
Required Course Work or Level of Knowledge
  • Statistics, intermediate - advanced
  • Machine Learning, introductory - advanced
Acceptable Level of Education (eg. Undergrad, Grad Students, Post Docs, MD, PhD)

Graduate students, Postgraduates, Full-time workers who volunteer time

CONTACT

PI/Research group

Sirota Lab

Contact

Marina Sirota, [email protected]